Pick a folder and a speed.
Start opens a short sheet: the folder inside Downloads, and how many worker tabs to run. Each tab takes its own slice of the catalog. Three or four tabs is the sweet spot; more can trip Mixamo's rate limits, and those items go to the failures list for a retry.
Your Mixamo export settings apply to every file: format, frames per second, keyframe reduction, skin, in place, pose and page range.